Anti-CD44 antibody,Abcam,AB157107
Product Specifications Anti-CD44 antibody (ab157107) is a rabbit polyclonal antibody and is validated for use in IHC-P, IP, WB in human, mouse, rat samples. Anti-CD44 antibody (ab157107) specifically detects CD44 (UniProt ID: P16070; Molecular weight: 79kDa) and is sold in 100 µL selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-CD44 antibody (ab157107) has high sensitivity and specificity. Anti-CD44 antibody (ab157107) has been cited over 188 times in peer reviewed journals and is trusted by the scientific community. Anti-CD44 antibody (ab157107) has 31 independent reviews from customers. Target Information CD44 is a cell-surface glycoprotein involved in various physiological functions such as cell proliferation, adhesion, migration, and lymphocyte activation. It plays a significant role in the pathology of diseases like cancer, arthritis, and infections by interacting with its principal ligand, hyaluronic acid. CD44 plays a significant role in autoimmune diseases by mediating inflammatory responses and immune cell interactions. It is involved in the activation and migration of lymphocytes, which are crucial in the development of autoimmune conditions. For instance, targeting CD44 with monoclonal antibodies has shown anti-inflammatory effects in murine models of autoimmune diseases like arthritis and experimental autoimmune encephalomyelitis (EAE)
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
WB, IP, IHC-P
Platform ID
BAB439667003
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data The protein expressed by gene CD44 functions as a cell-surface receptor involved in cell-cell interactions, cell adhesion, and migration, allowing cells to detect and react to changes in their tissue microenvironment. It is implicated in numerous cellular processes, including the activation, recirculation, and homing of T-lymphocytes, hematopoiesis, inflammation, and the response to bacterial infection. Through its ectodomain, CD44 interacts with extracellular matrix components like hyaluronan, collagen, growth factors, cytokines, and proteases, serving as a platform for signal transduction by forming protein complexes with receptor kinases and membrane proteases via its cytoplasmic domain. Effectors such as PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases, and phospholipase C coordinate signaling pathways that promote calcium mobilization and actin-mediated cytoskeleton reorganization crucial for cell migration and adhesion. This supplementary information is collated from multiple sources and compiled automatically. See full target information CD44
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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