Anti-CD45 antibody [F10-89-4] - Hematopoietic Stem Cell Marker,Abcam,AB30470
What is this antibody validated in? Anti-CD45 antibody [F10-89-4] - Hematopoietic Stem Cell Marker (ab30470) is a mouse monoclonal antibody and is validated for use in Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples. Trusted by the scientific community Anti-CD45 [F10-89-4] - Hematopoietic Stem Cell Marker (ab30470) was first used in a scientific publication in 2006 and has been cited over 10 times in peer-reviewed journals. Other related products We have a range of other formats of antibody clone [F10-89-4] also available for your convenience: ab30470, Alexa Fluor® 488 - ab197730 , Carrier free - ab230296 Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected]
Host
Mouse
Reactivity
Human
Application
IHC-P, ICC/IF, Flow Cyt
Platform ID
BAB002498094
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (PubMed : 35767951). Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).. (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. See full target information PTPRC
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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