Anti-CD45 antibody [MEM-28],Abcam,AB8216

Product Specifications Anti-CD45 antibody [MEM-28] (ab8216) is a mouse monoclonal antibody and is validated for use in Flow Cyt, ICC/IF, IHC-P, WB in human samples. Anti-CD45 antibody [MEM-28] (ab8216) specifically detects CD45 (UniProt ID: P08575; Molecular weight: 145kDa) and is sold in 100 µg selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-CD45 antibody [MEM-28] (ab8216) has high sensitivity and specificity. Anti-CD45 antibody [MEM-28] (ab8216) has been cited over 57 times in peer reviewed journals and is trusted by the scientific community. Related Products Antibody clone MEM-28 is also available pre-conjugated to a variety of labels for your convenience - APC, Biotin, PerCP, FITC, PE, PerCP/Cy5.5®, Alexa Fluor® 488, APC/Cy7®, PE/DyLight™ 594, Alexa Fluor® 647, PE/Cy7® ( ab28106 , ab28107 , ab65952 , ab134199 , ab134202 , ab157309 , ab187577 , ab197130 , ab223183 , ab239276 , ab239317 ).

Host

Mouse

Reactivity

Human

Application

IHC-P, WB, Flow Cyt, ICC/IF

Platform ID

BAB877535576

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-CD45 antibody [MEM-28]
Cat. No.AB8216
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationIHC-P, WB, Flow Cyt, ICC/IF
ClonalityMonoclonal
Clone NumberMEM-28
Concentration1 mg/mL Batch dependent concentration
ImmunogenCell preparation containing PTPRC protein. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (PubMed : 35767951). Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).. (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. See full target information PTPRC

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