Anti-CD63 antibody [EPR21151],Abcam,AB217345
Product Specifications Anti-CD63 antibody [EPR21151] (ab217345) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC/IF, WB in mouse samples. Anti-CD63 antibody [EPR21151] (ab217345) specifically detects CD63 (UniProt ID: P41731; Molecular weight: 26kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-CD63 antibody [EPR21151] (ab217345) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-CD63 antibody [EPR21151] (ab217345) has been cited over 147 times in peer reviewed journals and is trusted by the scientific community. Anti-CD63 antibody [EPR21151] (ab217345) has 5 independent reviews from customers. Related Products Conjugation-ready, carrier free format available for antibody clone EPR21151 - ab227892 . Antibody clone EPR21151 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, APC, PE, Alexa Fluor® 594, Alexa Fluor® 555 ( ab233055 , ab233056 , ab319310 , ab319449 , ab319803 , ab319944 ). Target Information CD63, also known as LAMP3 or Granulophysin, is a member of the tetraspanin family and is widely expressed on the surface of various cells, including macrophages and lymphocytes. It plays a crucial role in the formation and release of exosomes. CD63 (Granulophysin) is highly expressed in various tumor cells and also impacts the tumor microenvironment (TME) by regulating cell communication. Additionally, CD63 facilitates the degradation of the extracellular matrix, aiding in tumor cell invasion and metastasis. Species reactivity Human, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse
Application
ICC/IF, WB
Platform ID
BAB379084832
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. See full target information CD63 antigen
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
- Products>Trial Size Antibodies
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