Anti-CD63 antibody [EPR5702] - Late Endosome Marker,Abcam,AB134045

Product Specifications Anti-CD63 antibody [EPR5702] - Late Endosome Marker (ab134045) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IHC-P, WB in human samples. Anti-CD63 antibody [EPR5702] - Late Endosome Marker (ab134045) specifically detects CD63 (UniProt ID: P08962; Molecular weight: 26kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-CD63 antibody [EPR5702] - Late Endosome Marker (ab134045) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-CD63 antibody [EPR5702] - Late Endosome Marker (ab134045) has been confirmed by testing in knockout samples. Anti-CD63 antibody [EPR5702] - Late Endosome Marker (ab134045) has been cited over 379 times in peer reviewed journals and is trusted by the scientific community. Anti-CD63 antibody [EPR5702] - Late Endosome Marker (ab134045) has 5 independent reviews from customers. Related Products Conjugation-ready, carrier free format available for antibody clone EPR5702 - ab215821 . Antibody clone EPR5702 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 647 ( ab309976 , ab316180 ). Target Information CD63, also known as LAMP3 or Granulophysin, is a member of the tetraspanin family and is widely expressed on the surface of various cells, including macrophages and lymphocytes. It plays a crucial role in the formation and release of exosomes. CD63 (Granulophysin) is highly expressed in various tumor cells and also impacts the tumor microenvironment (TME) by regulating cell communication. Additionally, CD63 facilitates the degradation of the extracellular matrix, aiding in tumor cell invasion and metastasis. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Species reactivity Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.

Host

Rabbit

Reactivity

Human

Application

WB, IHC-P

Platform ID

BAB441666043

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-CD63 antibody [EPR5702] - Late Endosome Marker
Cat. No.AB134045
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationWB, IHC-P
ClonalityMonoclonal
Clone NumberEPR5702
Concentration0.368 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data The protein expressed by gene CD63 functions as a cell surface receptor for TIMP1 and is involved in the activation of various cellular signaling cascades. It plays a role in the activation of ITGB1 and integrin signaling, which leads to the activation of AKT, FAK/PTK2, and MAP kinases, promoting cell survival, actin cytoskeleton reorganization, and cell adhesion, spreading, and migration through the activation of AKT and FAK/PTK2. Additionally, it participates in VEGFA signaling by regulating the internalization of KDR/VEGFR2. CD63 is involved in intracellular vesicular transport processes and is essential for the normal trafficking of the PMEL luminal domain, crucial for melanocyte development and maturation. It also contributes to leukocyte adhesion onto endothelial cells by regulating SELP trafficking. CD63 may play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in response to other stimuli. This supplementary information is collated from multiple sources and compiled automatically. See full target information CD63

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