Anti-CD8 alpha antibody [C8/144B],Abcam,AB17147
Product Specifications Anti-CD8 alpha antibody [C8/144B] (ab17147) is a mouse monoclonal antibody and is validated for use in Flow Cyt, IHC-P in human samples. Anti-CD8 alpha antibody [C8/144B] (ab17147) specifically detects CD8 alpha (UniProt ID: P01732; Molecular weight: 24kDa) and is sold in 500 µL selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-CD8 alpha antibody [C8/144B] (ab17147) has high sensitivity and specificity. Anti-CD8 alpha antibody [C8/144B] (ab17147) has been cited over 103 times in peer reviewed journals and is trusted by the scientific community. Anti-CD8 alpha antibody [C8/144B] (ab17147) has 9 independent reviews from customers. Target Information CD8 alpha is a transmembrane glycoprotein acting as a co-receptor for the T-cell receptor (TCR), predominantly present on cytotoxic T cells. It is vital for T cell signaling and cytotoxic function by binding to MHC class I molecules, supporting the immune response against infected or cancerous cells. CD8 alpha is linked to various diseases, especially those related to immune system dysfunction
Host
Mouse
Reactivity
Human
Application
Flow Cyt, IHC-P
Platform ID
BAB818052877
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data The protein expressed by the gene CD8A is an integral membrane glycoprotein crucial for immune responses, operating mainly in T-cells as a coreceptor for MHC class I molecule : peptide complexes. These peptides originate from cytosolic proteins, unlike class II peptides, which are from extracellular proteins. CD8A interacts with the T-cell receptor (TCR) and MHC class I proteins on antigen-presenting cells, recruiting the Src kinase LCK to the TCR-CD3 complex. LCK phosphorylates substrates, triggering signaling pathways that lead to the production of lymphokines, enhanced motility, adhesion, and activation of cytotoxic T-lymphocytes (CTLs), thereby aiding in the recognition and elimination of infected or tumor cells. Additionally, in natural killer (NK) cells, CD8A homodimers on the cell surface provide a survival mechanism for conjugating with and lysing multiple target cells. CD8A homodimers also facilitate the survival and differentiation of activated lymphocytes into memory CD8 T-cells. This supplementary information is collated from multiple sources and compiled automatically. See full target information CD8A
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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