Anti-CD8 alpha antibody [CAL66],Abcam,AB237709
Product Specifications Anti-CD8 alpha antibody [CAL66] (ab237709) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt, ICC/IF, IHC-P, IP, mIHC in human, rat samples. Anti-CD8 alpha antibody [CAL66] (ab237709) specifically detects CD8 alpha (UniProt ID: P01732; Molecular weight: 24kDa) and is sold in a convenient trial size to enable initial testing (20 μL) and larger sizes for subsequent scaling up experiments (100 μL and 1 mL). Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-CD8 alpha antibody [CAL66] (ab237709) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-CD8 alpha antibody [CAL66] (ab237709) has been cited over 43 times in peer reviewed journals and is trusted by the scientific community. Related Products Conjugation-ready, carrier free format available for antibody clone CAL66 - ab251596 . Antibody clone CAL66 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 647, Alexa Fluor® 488, Alexa Fluor® 555, Alexa Fluor® 594 ( ab305048 , ab305220 , ab305367 , ab305370 ). Target Information CD8 alpha is a transmembrane glycoprotein that functions as a co-receptor for the T-cell receptor (TCR), mainly found on cytotoxic T cells. It plays a crucial role in T cell signaling and cytotoxic activity by binding to MHC class I molecules, aiding the immune response against infected or malignant cells. CD8 alpha is associated with several diseases, particularly those involving immune system dysfunction
Host
Rabbit
Reactivity
Rat, Human, Cat, Dog, Cow
Application
IP, Flow Cyt, ICC/IF, mIHC, IHC-P
Platform ID
BAB318102853
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data The protein expressed by the gene CD8A is an integral membrane glycoprotein crucial for immune responses, operating mainly in T-cells as a coreceptor for MHC class I molecule : peptide complexes. These peptides originate from cytosolic proteins, unlike class II peptides, which are from extracellular proteins. CD8A interacts with the T-cell receptor (TCR) and MHC class I proteins on antigen-presenting cells, recruiting the Src kinase LCK to the TCR-CD3 complex. LCK phosphorylates substrates, triggering signaling pathways that lead to the production of lymphokines, enhanced motility, adhesion, and activation of cytotoxic T-lymphocytes (CTLs), thereby aiding in the recognition and elimination of infected or tumor cells. Additionally, in natural killer (NK) cells, CD8A homodimers on the cell surface provide a survival mechanism for conjugating with and lysing multiple target cells. CD8A homodimers also facilitate the survival and differentiation of activated lymphocytes into memory CD8 T-cells. This supplementary information is collated from multiple sources and compiled automatically. See full target information CD8A
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
- Products>Trial Size Antibodies
Please provide the required information below so that we can quickly source your products.