Anti-CD8 alpha antibody [EPR21769],Abcam,AB217344
Anti-CD8 alpha antibody [EPR21769] (ab217344) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt, IHC-Fr IHC-P, IP and WB. Anti-CD8 alpha antibody [EPR21769] (ab217344) was first used in a scientific publication in 2019 and has been cited over 164 times in peer reviewed journals. It's performance in IHC and Immunofluorescence in mouse samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-CD8 alpha antibody [EPR21769] (ab217344) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-CD8 alpha antibody [EPR21769] (ab217344) has 4 independent reviews from customers. Anti-CD8 alpha antibody [EPR21769] (ab217344) specifically detects CD8 alpha (UniProt ID: P01731; Molecular weight: 25kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR21769 - ab230156 . Antibody clone EPR21769 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 488, Alexa Fluor ® 647, FITC, APC, Alexa Fluor ® 594, Alexa Fluor ® 555, PE ( ab237364 , ab237365 , ab237367 , ab237368 , ab277939 , ab280863 , ab306536 ). CD8 alpha is involved in diseases by aiding cytotoxic T cells in targeting and eliminating infected or malignant cells. CD8 T cell dysfunction is associated with several diseases including Autoimmune disease, cancer and infectious diseases. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse
Application
IP, Flow Cyt, IHC-Fr, WB, IHC-P
Platform ID
BAB443165323
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule : peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. See full target information Cd8a
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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