Anti-CD8 alpha antibody [SP16],Abcam,AB101500
Product Specifications Anti-CD8 alpha antibody [SP16] (ab101500) is a rabbit recombinant monoclonal antibody and is validated for use in Flow Cyt, IHC-P in human samples. Anti-CD8 alpha antibody [SP16] (ab101500) specifically detects CD8 alpha (UniProt ID: P01732; Molecular weight: 24kDa) and is sold in 100 µL, 500 µL and 1 mL selling sizes. Quality and Validation Anti-CD8 alpha antibody [SP16] (ab101500) is a clone from the portfolio of Spring Bioscience (Roche) SP clones which have been optimised for immunohistochemistry (IHC). Abcam's high quality manufacturing and validation processes ensure Anti-CD8 alpha antibody [SP16] (ab101500) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-CD8 alpha antibody [SP16] (ab101500) has been cited over 53 times in peer reviewed journals and is trusted by the scientific community. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human
Application
IHC-P, Flow Cyt
Platform ID
BAB130759028
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data The protein expressed by the gene CD8A is an integral membrane glycoprotein crucial for immune responses, operating mainly in T-cells as a coreceptor for MHC class I molecule : peptide complexes. These peptides originate from cytosolic proteins, unlike class II peptides, which are from extracellular proteins. CD8A interacts with the T-cell receptor (TCR) and MHC class I proteins on antigen-presenting cells, recruiting the Src kinase LCK to the TCR-CD3 complex. LCK phosphorylates substrates, triggering signaling pathways that lead to the production of lymphokines, enhanced motility, adhesion, and activation of cytotoxic T-lymphocytes (CTLs), thereby aiding in the recognition and elimination of infected or tumor cells. Additionally, in natural killer (NK) cells, CD8A homodimers on the cell surface provide a survival mechanism for conjugating with and lysing multiple target cells. CD8A homodimers also facilitate the survival and differentiation of activated lymphocytes into memory CD8 T-cells. This supplementary information is collated from multiple sources and compiled automatically. See full target information CD8A
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
- Products>Trial Size Antibodies
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