Anti-CD86 antibody [GL-1],Abcam,AB119857

What is this antibody validated in? Anti-CD86 antibody [GL-1] (ab119857) is a rat monoclonal antibody and is validated for use in Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunocytochemistry/immunofluorescence (ICC/IF), Functional Studies, Blocking in Mouse samples. Trusted by the scientific community Anti-CD86 [GL-1] (ab119857) was first used in a scientific publication in 2011 and has been cited over 30 times in peer-reviewed journals. Other related products We have a range of other formats of antibody clone [GL-1] also available for your convenience: ab119857, FITC - ab234237

Host

Rat

Reactivity

Mouse

Application

ICC/IF, Flow Cyt, IP

Platform ID

BAB068877481

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-CD86 antibody [GL-1]
Cat. No.AB119857
HostRat
IsotypeIgG2a
ReactivityMouse
ApplicationICC/IF, Flow Cyt, IP
ClonalityMonoclonal
Clone NumberGL-1
Concentration2 mg/mL Batch dependent concentration
ImmunogenCell preparation containing Cd86 protein. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.87% Sodium chloride, 0.14% Sodium dihydrogen phosphate
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (PubMed : 23241883). See full target information Cd86

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