Anti-CDC42 antibody [EPR15620],Abcam,AB187643
What is this antibody validated in? Anti-CDC42 antibody [EPR15620] (ab187643) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples. What is the molecular weight of CDC42? Anti-CDC42 [EPR15620] (ab187643) specifically detects a band for CDC42 (UniProt: P60953) at a molecular weight of 21kDa. Trusted by the scientific community Anti-CDC42 [EPR15620] (ab187643) was first used in a scientific publication in 2014 and has been cited over 50 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-CDC42 antibody [EPR15620] (ab187643) has been confirmed by Western blot testing in CDC42 Knockout HAP1 cell line, ab266522 . Other related products We have a range of other formats of antibody clone [EPR15620] also available for your convenience: ab187643, Alexa Fluor® 488 - ab214952 , Alexa Fluor® 647 - ab215234 , HRP - ab215810 , Carrier free - ab221781 , APC - ab225345 , PE - ab225346 , Carrier free - ab271953 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
WB, Flow Cyt (Intra), IHC-P, ICC/IF
Platform ID
BAB444864507
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase (PubMed : 15642749). Regulates cell migration (PubMed : 17038317, PubMed : 22843693). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (PubMed : 14978216). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. In podocytes, facilitates filopodia and podosomes formation upon DOCK11-activation (PubMed : 33523862). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (PubMed : 26465210). Upon activation by PLEKHG4B, involved in actin cytoskeletal remodeling during epithelial cell-cell junction formation (PubMed : 33310911). See full target information Cell division control protein 42 homolog
Category Paths
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