Anti-CDK11A/CDK11B antibody,Abcam,AB198813

Target data Cyclin-dependent protein kinase that acts as a regulator of transcription and pre-mRNA splicing (PubMed : 12501247, PubMed : 18216018, PubMed : 32367068, PubMed : 36104565). Acts as a key regulator of pre-mRNA splicing by mediating phosphorylation of SF3B1, enabling the association between SF3B1 and U5 and U6 snRNAs in the activated spliceosome, thereby promoting spliceosome assembly (PubMed : 36104565, PubMed : 38059508). Also acts as a regulator of transcription by phosphorylating 'Ser-2' of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed : 32367068, PubMed : 40858114). Involved in replication-dependent transcription of histone genes : binds to histone genes and phosphorylates POLR2A at 'Ser-2' of the CTD to specifically control transcriptional elongation of histones and recruitment of 3'-end processing factors (PubMed : 32367068). Part of a transcription checkpoint upstream of CDK9, which regulates promoter-proximal pausing by RNA polymerase II, a transcription halt following transcription initiation, but prior to elongation (PubMed : 40858114). Probably regulates promoter-proximal pausing by mediating phosphorylation of POLR2A at 'Ser-2' of the CTD (PubMed : 40858114).. Isoform SV9. Isoform expressed in a non-cell cycle-dependent manner.. Isoform 7. Isoform specifically expressed during the G2-M phases of the cell cycle (PubMed : 12082095, PubMed : 2217177). Phosphorylates 'Ser-2' of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed : 38019613). Promotes centromeric transcription to maintain centromeric cohesion during mitosis (PubMed : 24436071, PubMed : 38019613). See full target information CDK11B Additional targets CDK11A