Anti-CDK5RAP1 antibody,Abcam,AB154537

Host

Rabbit

Reactivity

Human

Application

IHC-P, WB, ICC/IF

Platform ID

BAB445664123

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-CDK5RAP1 antibody
Cat. No.AB154537
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIHC-P, WB, ICC/IF
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human CDK5RAP1 aa 300-600. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed : 22422838, PubMed : 25738458, PubMed : 28981754). Essential for efficient and highly accurate protein translation by the ribosome (PubMed : 22422838, PubMed : 25738458, PubMed : 28981754). Specifically inhibits CDK5 activation by CDK5R1 (PubMed : 11882646). Essential for efficient mitochondrial protein synthesis and respiratory chain; shows pathological consequences in mitochondrial disease (PubMed : 25738458). See full target information CDK5RAP1

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