Anti-CDKN2A/p16INK4a antibody [EPR1473] - C-terminal,Abcam,AB108349
Anti-CDKN2A/p16INK4a antibody [EPR1473] - C-terminal (ab108349) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), IHC-P, IP and WB. Anti-CDKN2A/p16INK4a antibody [EPR1473] - C-terminal (ab108349) was first used in a scientific publication in 2013 and has been cited over 192 times in peer reviewed journals. It's performance in Western Blot and IHC in human samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-CDKN2A/p16INK4a antibody [EPR1473] - C-terminal (ab108349) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-CDKN2A/p16INK4a antibody [EPR1473] - C-terminal (ab108349) has been confirmed by Western Blot testing in CDKN2A/p16INK4a knockout HEK-293T cells. Anti-CDKN2A/p16INK4a antibody [EPR1473] - C-terminal (ab108349) has 6 independent reviews from customers. Anti-CDKN2A/p16INK4a antibody [EPR1473] - C-terminal (ab108349) specifically detects CDKN2A/p16INK4a (UniProt ID: P42771; Molecular weight: 17kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL). Conjugation-ready, carrier free format available for antibody clone EPR1473 - ab186932 . Antibody clone EPR1473 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 647, PE ( ab192054 , ab209579 ). CDKN2A, encoding the tumor suppressor protein p16INK4a, plays a crucial role in regulating the cell cycle by inhibiting cyclin-dependent kinases, thereby preventing uncontrolled cell proliferation. Mutations or deletions in CDKN2A are frequently associated with various cancers, including melanoma, pancreatic cancer and head and neck squamous cell carcinoma. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human
Application
WB, IHC-P, IP, Flow Cyt (Intra)
Platform ID
BAB696088919

Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Product Specifications
Scientific Background
Specifications
NameAnti-CDKN2A/p16INK4a antibody [EPR1473] - C-terminal
Cat. No.AB108349
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationWB, IHC-P, IP, Flow Cyt (Intra)
ClonalityMonoclonal
Clone NumberEPR1473
Concentration1.331 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingConditional Ambient
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only
Scientific Background
Target data The protein expressed by the gene CDKN2A acts as a negative regulator of normal cell proliferation by strongly interacting with CDK4 and CDK6. This interaction inhibits the ability of CDK4 and CDK6 to interact with cyclins D and to phosphorylate the retinoblastoma protein. This supplementary information is collated from multiple sources and compiled automatically. See full target information CDKN2A
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
- Products>Trial Size Antibodies
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