Anti-CDX2 antibody [EPR2764Y],Abcam,AB76541
Anti-CDX2 antibody [EPR2764Y] (ab76541) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ChIC/CUT&RUN-seq, ICC/IF, IHC-P, WB in human, mouse, rat samples. Anti-CDX2 antibody [EPR2764Y] (ab76541) has been cited over 134 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality manufacturing and validation processes ensure Anti-CDX2 antibody [EPR2764Y] (ab76541) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-CDX2 antibody [EPR2764Y] (ab76541) has 18 independent reviews from customers. Anti-CDX2 antibody [EPR2764Y] (ab76541) specifically detects CDX2 (UniProt ID: Q99626; Molecular weight: 34kDa) and is sold in 100 uL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR2764Y - ab22799 . Antibody clone EPR2764Y is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, PE, APC, HRP, Alkaline Phosphatase, Alexa Fluor® 555, Alexa Fluor® 568 ( ab1957 , ab1958 , ab338, ab339, ab331, ab38964 , ab312266 , ab312755 ). CDX2 is a critical transcription factor involved in intestinal differentiation and is widely used as a prognostic marker in colorectal cancer. Utilizing immunohistochemistry for CDX2 detection can significantly aid in diagnosing and determining the origin of metastatic adenocarcinomas. Research indicates that CDX2 expression is associated with better prognosis and can help guide therapeutic decisions. Validated also for CUT&RUN, which is a key applications to map protein-DNA interactions on a genome-wide scale using NGS. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
IHC-P, WB, ICC/IF, ChIC/CUT&RUN-seq
Platform ID
BAB258920010
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed : 28473536). See full target information CDX2
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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