Anti-CEBP Beta antibody [E299] - C-terminal,Abcam,AB32358
What is this antibody validated in? Anti-CEBP Beta antibody [E299] - C-terminal (ab32358) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples. What is the molecular weight of CEBP Beta? Anti-CEBP Beta [E299] - C-terminal (ab32358) specifically detects a band for CEBP Beta (UniProt: P21272) at a molecular weight of 36kDa. Trusted by the scientific community Anti-CEBP Beta [E299] - C-terminal (ab32358) was first used in a scientific publication in 2006 and has been cited over 100 times in peer-reviewed journals. Reviewed by scientists Anti-CEBP Beta [E299] - C-terminal (ab32358) has over 5 independent reviews from customers. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-CEBP Beta antibody [E299] - C-terminal (ab32358) has been confirmed by Western blot testing in CEBPB Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [E299] also available for your convenience: ab32358, Carrier free - ab220813 , Alexa Fluor® 488 - ab237414 , Alexa Fluor® 647 - ab237415 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
WB, Flow Cyt (Intra), IP, ICC/IF
Platform ID
BAB071876041
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed : 12048245, PubMed : 1741402, PubMed : 18647749, PubMed : 9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed : 20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis : together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity).. Isoform 2. Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing.. Isoform 3. Acts as a dominant negative through heterodimerization with isoform 2 (PubMed : 11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). See full target information CEBPB
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