Anti-CENPA antibody [EP800Y] - Centromere Marker,Abcam,AB45694

Target data Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed : 11756469, PubMed : 14667408, PubMed : 15282608, PubMed : 15475964, PubMed : 15702419, PubMed : 17651496, PubMed : 19114591, PubMed : 20739937, PubMed : 27499292, PubMed : 7962047, PubMed : 9024683). Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore (PubMed : 18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed : 26878239, PubMed : 27499292). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed : 15282608, PubMed : 15475964, PubMed : 20739937, PubMed : 21478274, PubMed : 26878239). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed : 11756469, PubMed : 14667408, PubMed : 18072184, PubMed : 23818633, PubMed : 25556658, PubMed : 27499292). See full target information CENPA