Anti-CENPF antibody,Abcam,AB5
Product Specifications Anti-CENPF antibody (ab5) is a Rabbit Polyclonal antibody and is validated for use in Flow Cyt, ICC, ICC/IF, IHC-P, IP, WB in human, mouse samples. Anti-CENPF antibody (ab5) specifically detects CENPF (UniProt ID: P49454; Molecular weight: 357kDa) and is sold in 50 µL selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-CENPF antibody (ab5) has high sensitivity and specificity. Anti-CENPF antibody (ab5) has been cited over 108 times in peer reviewed journals and is trusted by the scientific community. Anti-CENPF antibody (ab5) has 7 independent reviews from customers. Target Information CENPF (Centromere Protein F) is a key protein that participates in cell cycle regulation and chromosome movement during mitosis. It is essential for proper cell division and genomic stability. Abnormal expression of CENPF is associated with several diseases, particularly cancer, where it promotes tumor growth and metastasis. High CENPF levels are observed in cancers like colorectal cancer and are linked to worse clinical outcomes. CENPF is also involved in cardiac development and diseases such as dilated cardiomyopathy.
Host
Rabbit
Reactivity
Human, Mouse
Application
IHC-P, IP, ICC, Flow Cyt, ICC/IF, WB
Platform ID
BAB572325825
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia. See full target information Centromere protein F
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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