Anti-CGRP antibody,Abcam,AB36001

Product Specifications Anti-CGRP antibody (ab36001) is a goat polyclonal antibody and is validated for use in ELISA, IHC-FoFr, IHC-Fr, IHC-P in mouse, rat samples. Anti-CGRP antibody (ab36001) specifically detects CGRP (UniProt ID: P01256; Molecular weight: 14kDa) and is sold in 100 µL selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-CGRP antibody (ab36001) has high sensitivity and specificity. Anti-CGRP antibody (ab36001) has been cited over 144 times in peer reviewed journals and is trusted by the scientific community. Anti-CGRP antibody (ab36001) has 12 independent reviews from customers. Target Information CGRP (Calcitonin Gene-Related Peptide) is a significant neuropeptide extensively studied in neuroscience. Its role is particularly noted in various neurodegenerative conditions, including Alzheimer's disease (AD). CGRP is involved in modulating inflammation and neuroprotection, making it a valuable marker for assessing neuroinflammatory responses. In AD, changes in CGRP expression can provide insights into the disease's progression and the associated inflammatory processes. This highlights CGRP's importance in understanding and potentially targeting neuroinflammation.

Host

Goat

Reactivity

Mouse, Rat

Application

IHC-Fr, IHC-P, IHC-FoFr, ELISA

Platform ID

BAB385781616

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-CGRP antibody
Cat. No.AB36001
HostGoat
IsotypeIgG
ReactivityMouse, Rat
ApplicationIHC-Fr, IHC-P, IHC-FoFr, ELISA
ClonalityPolyclonal
Concentration5 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex. See full target information Calca

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