Anti-CHD1L antibody,Abcam,AB237768

Host

Rabbit

Reactivity

Human

Application

WB, ICC/IF

Platform ID

BAB636006508

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-CHD1L antibody
Cat. No.AB237768
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationWB, ICC/IF
ClonalityPolyclonal
ImmunogenRecombinant Fragment Protein within Human CHD1L aa 700 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage (PubMed : 19661379, PubMed : 29220652, PubMed : 29220653, PubMed : 33357431, PubMed : 34210977, PubMed : 34486521, PubMed : 34874266). Recruited to DNA damage sites through interaction with poly-ADP-ribose : specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage (PubMed : 19661379, PubMed : 29220652, PubMed : 29220653, PubMed : 34486521, PubMed : 34874266). Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair (PubMed : 19661379, PubMed : 29220652, PubMed : 29220653, PubMed : 34486521, PubMed : 34874266). Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner (PubMed : 19661379, PubMed : 29220652, PubMed : 29220653). Chromatin remodeling activity promotes PARP2 removal from chromatin (PubMed : 33275888). See full target information CHD1L

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