Anti-CHD1L antibody [EPR14515(2)],Abcam,AB197019

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Mouse, Human

Application

Flow Cyt (Intra), IHC-P, IP, WB, ICC/IF

Platform ID

BAB948512755

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-CHD1L antibody [EPR14515(2)]
Cat. No.AB197019
HostRabbit
IsotypeIgG
ReactivityMouse, Human
ApplicationFlow Cyt (Intra), IHC-P, IP, WB, ICC/IF
ClonalityMonoclonal
Clone NumberEPR14515(2)
Concentration1.312 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage (PubMed : 19661379, PubMed : 29220652, PubMed : 29220653, PubMed : 33357431, PubMed : 34210977, PubMed : 34486521, PubMed : 34874266). Recruited to DNA damage sites through interaction with poly-ADP-ribose : specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage (PubMed : 19661379, PubMed : 29220652, PubMed : 29220653, PubMed : 34486521, PubMed : 34874266). Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair (PubMed : 19661379, PubMed : 29220652, PubMed : 29220653, PubMed : 34486521, PubMed : 34874266). Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner (PubMed : 19661379, PubMed : 29220652, PubMed : 29220653). Chromatin remodeling activity promotes PARP2 removal from chromatin (PubMed : 33275888). See full target information CHD1L

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