Anti-CHD5 antibody [EPR27395-47],Abcam,AB307831

Target data Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription (PubMed : 23318260). May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 (PubMed : 23318260, PubMed : 23948251). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed : 27806305). Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation (PubMed : 23948251, PubMed : 27806305). In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages (PubMed : 23948251). Regulates the expression of genes involved in cell proliferation and differentiation (PubMed : 17289567). Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation (PubMed : 17289567). In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa (PubMed : 24252660). See full target information Chd5