Anti-CK1 epsilon antibody [1/Casein Kinase Iε],Abcam,AB302638

What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected]

Host

Mouse

Reactivity

Human, Mouse, Rat

Application

WB, ICC/IF

Platform ID

BAB575624241

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-CK1 epsilon antibody [1/Casein Kinase Iε]
Cat. No.AB302638
HostMouse
IsotypeIgG1
ReactivityHuman, Mouse, Rat
ApplicationWB, ICC/IF
ClonalityMonoclonal
Clone Number1-Casein Kinase Iε
Concentration0.991 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed : 12556519, PubMed : 23413191). Phosphorylates DVL1 (PubMed : 12556519). Phosphorylates DVL2 (PubMed : 23413191). Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock (PubMed : 16790549). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed : 15917222, PubMed : 16790549). Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation (PubMed : 15070676). See full target information CSNK1E

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