Anti-CLIC5 antibody [CLIC502],Abcam,AB191102

Target data In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form non-selective ion channels almost equally permeable to Na(+), K(+) and Cl(-) (PubMed : 15184393, PubMed : 18028448). Required for normal hearing (PubMed : 24781754). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed : 15184393, PubMed : 18028448, PubMed : 20335315). Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens (By similarity). See full target information CLIC5