Anti-CLN5 antibody [EPR12197(B)],Abcam,AB170899
What is this antibody validated in? Anti-CLN5 antibody [EPR12197(B)] (ab170899) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples. What is the molecular weight of CLN5? Anti-CLN5 [EPR12197(B)] (ab170899) specifically detects a band for CLN5 (UniProt: O75503) at a molecular weight of 41kDa. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Other related products We have a range of other formats of antibody clone [EPR12197(B)] also available for your convenience: ab170899, Carrier free - ab238931 , PE - ab317909 , APC - ab317948 , Alexa Fluor® 488 - ab317989 , Alexa Fluor® 594 - ab318031 , Alexa Fluor® 555 - ab318073 , Alexa Fluor® 647 - ab318114 , Alexa Fluor® 750 - ab321166 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
ICC/IF, WB, IHC-P
Platform ID
BAB639804684
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Bis(monoacylglycero)phosphate synthase CLN5, secreted form. Catalyzes the synthesis of bis(monoacylglycero)phosphate (BMP) via transacylation of 2 molecules of lysophosphatidylglycerol (LPG) (PubMed : 37708259). BMP also known as lysobisphosphatidic acid plays a key role in the formation of intraluminal vesicles and in maintaining intracellular cholesterol homeostasis (PubMed : 37708259). Can use only LPG as the exclusive lysophospholipid acyl donor for base exchange and displays BMP synthase activity towards various LPGs (LPG 14 : 0, LPG 16 : 0, LPG 18 : 0, LPG 18 : 1) with a higher preference for longer chain lengths (PubMed : 37708259). Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane (PubMed : 22431521). Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane (PubMed : 22431521).. Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation. See full target information Ceroid-lipofuscinosis neuronal protein 5
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
Please provide the required information below so that we can quickly source your products.