Anti-CNOT4 antibody,Abcam,AB214937

Host

Rabbit

Reactivity

Human

Application

IHC-P, WB

Platform ID

BAB077973113

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-CNOT4 antibody
Cat. No.AB214937
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIHC-P, WB
ClonalityPolyclonal
Concentration0.1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human CNOT4 aa 300-500. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed : 11823428, PubMed : 22159038, PubMed : 26575292). Involved in activation of the JAK/STAT pathway (PubMed : 11823428, PubMed : 22159038). Catalyzes ubiquitination of methylated RBM15 (PubMed : 26575292). Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed : 29861391). As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed : 29861391). See full target information CNOT4

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