Anti-COX IV antibody [EPR9442(ABC)] - Mitochondrial Loading Control,Abcam,AB202554
What is this antibody validated in? Anti-COX IV antibody [EPR9442(ABC)] - Mitochondrial Loading Control (ab202554) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF), Multiplex IHC (mIHC) in Human, Mouse, Rat samples. What is the molecular weight of COX IV? Anti-COX IV [EPR9442(ABC)] - Mitochondrial Loading Control (ab202554) is often used as a loading control in Western blot. It specifically detects a band for COX IV (UniProt: P13073) at a molecular weight of 20kDa. Trusted by the scientific community Anti-COX IV [EPR9442(ABC)] - Mitochondrial Loading Control (ab202554) was first used in a scientific publication in 2015 and has been cited over 30 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Other related products We have a range of other formats of antibody clone [EPR9442(ABC)] also available for your convenience: ab202554, HRP - ab209958 , Alexa Fluor® 405 - ab210180 , Alexa Fluor® 594 - ab210674 , Alexa Fluor® 555 - ab210675 , Carrier free - ab231168 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
WB, IHC-P, mIHC, ICC/IF, IP, Flow Cyt (Intra)
Platform ID
BAB142853220
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. See full target information COX4I1
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