Anti-CPT1A antibody [8F6AE9],Abcam,AB128568
Anti-CPT1A antibody [8F6AE9] (ab128568) is a House Mouse Monoclonal antibody and is validated for use in Flow Cyt, ICC/IF, IHC-P, In-Cell ELISA, WB in human, rat samples. Anti-CPT1A antibody [8F6AE9] (ab128568) has been cited over 179 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality validation processes ensure Anti-CPT1A antibody [8F6AE9] (ab128568) has high sensitivity and specificity. The specificity of Anti-CPT1A antibody [8F6AE9] (ab128568) has been confirmed by testing in knockout samples. Anti-CPT1A antibody [8F6AE9] (ab128568) has 5 independent reviews from customers. Anti-CPT1A antibody [8F6AE9] (ab128568) specifically detects CPT1A (UniProt ID: P50416; Molecular weight: 88kDa) and is sold in 100 ug selling sizes. Antibody clone 8F6AE9 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, HRP ( ab171449 , ab198494 ). CPT1A is crucial in fatty acid oxidation, and its dysfunction is linked to metabolic disorders, diabetic nephropathy, and certain cancers This monoclonal antibody to CPT1A has been knockout validated in Western blot. The expected band for CPT1A was observed in wild type cells and the band was not seen in CPT1A knockout cells. Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected]
Host
Mouse
Reactivity
Mouse, Rat, Human
Application
Flow Cyt, IHC-P, WB, ICC/IF, In-Cell ELISA
Platform ID
BAB393777776
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed : 11350182, PubMed : 14517221, PubMed : 16651524, PubMed : 9691089). Possesses also a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity (PubMed : 29425493). Plays an important role in hepatic triglyceride metabolism (By similarity). Plays also a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression (By similarity). Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (PubMed : 38016475). Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways (By similarity). See full target information CPT1A
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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