Anti-CRBN antibody [4D6],Abcam,AB244223
What is this antibody validated in? Anti-CRBN antibody [4D6] (ab244223) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human, Mouse samples. What is the molecular weight of CRBN? Anti-CRBN [4D6] (ab244223) specifically detects a band for CRBN (UniProt: Q96SW2) at a molecular weight of 51kDa. Specificity confirmed The specificity of Anti-CRBN antibody [4D6] (ab244223) has been confirmed by Western blot testing in CRBN Knockout MOLT 4 cells. Other related products We have a range of other formats of antibody clone [4D6] also available for your convenience: ab244223, Carrier free - ab252776 Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected]
Host
Mouse
Reactivity
Mouse, Human
Application
IHC-P, WB
Platform ID
BAB769065138
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2, ILF2 or GLUL (PubMed : 26990986, PubMed : 33009960). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (PubMed : 20223979, PubMed : 24328678, PubMed : 25043012, PubMed : 25108355). Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons (PubMed : 18414909, PubMed : 29530986). Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (PubMed : 18414909). May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (By similarity). Plays a negative role in TLR4 signaling by interacting with TRAF6 and ECSIT, leading to inhibition of ECSIT ubiquitination, an important step of the signaling (PubMed : 31620128). See full target information CRBN
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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