Anti-CREB (phospho S133) antibody [E113],Abcam,AB32096

Product Specifications Anti-CREB (phospho S133) antibody [E113] (ab32096) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, IP, WB in human, mouse, rat samples. Anti-CREB (phospho S133) antibody [E113] (ab32096) specifically detects CREB Phospho-S133 (UniProt ID: P16220; Molecular weight: 35kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL). Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-CREB (phospho S133) antibody [E113] (ab32096) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-CREB (phospho S133) antibody [E113] (ab32096) has been cited over 230 times in peer reviewed journals and is trusted by the scientific community. Anti-CREB (phospho S133) antibody [E113] (ab32096) has 13 independent reviews from customers. Related Products Conjugation-ready, carrier free format available for antibody clone E113 - ab220798 . Antibody clone E113 is also available pre-conjugated to a variety of labels for your convenience - HRP ( ab219741 ). Target Information CREB (phospho S133) is a transcription factor that plays a vital role in regulating gene expression upon phosphorylation at serine 133. This phosphorylation enhances CREB's ability to activate genes involved in cell survival, metabolism, and proliferation. Dysregulation of CREB phosphorylation at S133 is implicated in several conditions, including cancer, where it aids in tumor development and resistance to apoptosis, and neurodegenerative disorders such as Alzheimer's disease, where it influences neuronal resilience and cognitive function. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

ICC/IF, Dot, Flow Cyt (Intra), WB, IP, IHC-P

Platform ID

BAB644302524

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-CREB (phospho S133) antibody [E113]
Cat. No.AB32096
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationICC/IF, Dot, Flow Cyt (Intra), WB, IP, IHC-P
ClonalityMonoclonal
Clone NumberE113
Concentration0.691 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed : 14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity). See full target information CREB1 phospho S133

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.