Anti-CTLA4 antibody [CAL49],Abcam,AB237712

What is this antibody validated in? Anti-CTLA4 antibody [CAL49] (ab237712) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P) in Human, Mouse, Rhesus monkey samples. What is the molecular weight of CTLA4? Anti-CTLA4 [CAL49] (ab237712) specifically detects a band for CTLA4 (UniProt: P16410) at a molecular weight of 25kDa. Trusted by the scientific community Anti-CTLA4 [CAL49] (ab237712) was first used in a scientific publication in 2018 and has been cited over 20 times in peer-reviewed journals. Reviewed by scientists Anti-CTLA4 [CAL49] (ab237712) has over 5 independent reviews from customers. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10μl. Discover our selection of trial-size antibodies. Other related products We have a range of other formats of antibody clone [CAL49] also available for your convenience: ab237712, Carrier free - ab251599 , Alexa Fluor® 647 - ab270127 , PE - ab270128 , Alexa Fluor® 555 - ab283489

Host

Rabbit

Reactivity

Mouse, Human, Rhesus monkey

Application

IHC-P, IP, WB, Flow Cyt (Intra)

Platform ID

BAB834145149

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-CTLA4 antibody [CAL49]
Cat. No.AB237712
HostRabbit
IsotypeIgG
ReactivityMouse, Human, Rhesus monkey
ApplicationIHC-P, IP, WB, Flow Cyt (Intra)
ClonalityMonoclonal
Clone NumberCAL49
Concentration0.405 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Inhibitory receptor acting as a major negative regulator of T-cell responses (PubMed : 11279501, PubMed : 11279502, PubMed : 16551244, PubMed : 1714933, PubMed : 18641304, PubMed : 28484017). Acts as a decoy receptor : the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (PubMed : 11279501, PubMed : 11279502, PubMed : 16551244, PubMed : 1714933, PubMed : 28484017). See full target information CTLA4

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