Anti-CXCR4 antibody [UMB2],Abcam,AB124824
Product Specifications Anti-CXCR4 antibody [UMB2] (ab124824) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-Fr, IHC-P, WB in human, mouse, rat samples. Anti-CXCR4 antibody [UMB2] (ab124824) specifically detects CXCR4 (UniProt ID: P61073; Molecular weight: 40kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-CXCR4 antibody [UMB2] (ab124824) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-CXCR4 antibody [UMB2] (ab124824) has been cited over 238 times in peer reviewed journals and is trusted by the scientific community. Anti-CXCR4 antibody [UMB2] (ab124824) has 12 independent reviews from customers. Related Products Conjugation-ready, carrier free format available for antibody clone UMB2 - ab197203 . Antibody clone UMB2 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, Alexa Fluor® 555, Alexa Fluor® 594 ( ab208128 , ab208129 , ab211982 , ab211984 ). Target Information CXCR4 (fusin), also known as C-X-C chemokine receptor type 4 or CD184, is a protein encoded by the CXCR4 gene in humans. CXCR4 or CD184 protein is a receptor for the chemokine CXCL12 (SDF-1) and plays a significant role in oncology due to its involvement in tumor growth, metastasis, and the tumor microenvironment. CXCR4 and its ligand CXCL12 are crucial for the metastatic spread of cancer cells to organs where CXCL12 is expressed, such as the bone marrow, liver, and lungs. The CXCR4-CXCL12 axis helps tumor cells find niches that support their survival and growth. Our internal data indicates that rat is not recommended for IHC. Abcam recommended secondaries - Goat Anti-Rabbit HRP ( ab205718 ) and Goat Anti-Rabbit Alexa Fluor® 488 ( ab150077 ). Or search our wide range of secondary antibodies for use with your experiment. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
ICC/IF, WB, IHC-P, Flow Cyt (Intra)
Platform ID
BAB335794357
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed : 10074102, PubMed : 10452968, PubMed : 10644702, PubMed : 10825158, PubMed : 18799424, PubMed : 20048153, PubMed : 20505072, PubMed : 24912431, PubMed : 28978524, PubMed : 8752280, PubMed : 8752281). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed : 16725153, PubMed : 17197449, PubMed : 18799424, PubMed : 39093700). CXCR4 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase (PubMed : 17197449, PubMed : 39093700). Involved in the AKT signaling cascade (PubMed : 24912431). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed : 28978524). Also acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed : 20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed : 11276205). Involved in hematopoiesis and in cardiac ventricular septum formation (By similarity). Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells (By similarity). Involved in cerebellar development; in the CNS, could mediate hippocampal-neuron surviva (By similarity).. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed : 10074122, PubMed : 10756055, PubMed : 8849450, PubMed : 8929542, PubMed : 9427609). See full target information CXCR4
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
- Products>Trial Size Antibodies
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