Anti-Calcitonin receptor/CT-R antibody,Abcam,AB230500

Target data G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA) (PubMed : 35324283, PubMed : 38603770). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively (PubMed : 35324283, PubMed : 38603770). IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes (PubMed : 35324283, PubMed : 38603770). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed : 35324283, PubMed : 7476993).. Isoform 2. Non-functional protein. Unable to couple to G proteins and activate adenylyl cyclase (PubMed : 7476993). Does not undergo receptor internalization following ligand binding (PubMed : 7476993). See full target information CALCR