Anti-Calnexin antibody [EPR3633(2)] - ER Membrane Marker,Abcam,AB133615

Anti-Calnexin antibody [EPR3633(2)] - ER Membrane Marker (ab133615) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), IHC-P, WB in human samples. Anti-Calnexin antibody [EPR3633(2)] - ER Membrane Marker (ab133615) has been cited over 78 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-Calnexin antibody [EPR3633(2)] - ER Membrane Marker (ab133615) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-Calnexin antibody [EPR3633(2)] - ER Membrane Marker (ab133615) has been confirmed by testing in knockout samples. Anti-Calnexin antibody [EPR3633(2)] - ER Membrane Marker (ab133615) specifically detects Calnexin (UniProt ID: P27824; Molecular weight: 65kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR3633(2) - ab225542 . Antibody clone EPR3633(2) is also available pre-conjugated to a variety of labels for your convenience - HRP, Alexa Fluor® 594, APC, PE, Alexa Fluor® 488, Alexa Fluor® 647, Alexa Fluor® 568, Alexa Fluor® 555 ( ab195198 , ab203439 , ab310822 , ab310899 , ab310982 , ab311104 , ab312999 , ab313204 ). References regarding specificity: Horner SM et al. Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus. Proc Natl Acad Sci U S A 108:14590-5 (2011). PubMed: 21844353 Myhill N et al. The subcellular distribution of calnexin is mediated by PACS-2. Mol Biol Cell 19:2777-88 (2008). PubMed: 18417615 Yoshimura SI et al. Direct targeting of cis-Golgi matrix proteins to the Golgi apparatus. J Cell Sci 114:4105-15 (2001). PubMed: 11739642 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Human

Application

Flow Cyt (Intra), IHC-P, WB

Platform ID

BAB924924083

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Calnexin antibody [EPR3633(2)] - ER Membrane Marker
Cat. No.AB133615
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationFlow Cyt (Intra), IHC-P, WB
ClonalityMonoclonal
Clone NumberEPR3633(2)
Concentration1.863 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. See full target information CANX

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