Anti-Calreticulin antibody [EPR3924] - ER Marker,Abcam,AB92516

Anti-Calreticulin antibody [EPR3924] - ER Marker (ab92516) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, WB in african green monkey, human, mouse, rat samples. Anti-Calreticulin antibody [EPR3924] - ER Marker (ab92516) has been cited over 100 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-Calreticulin antibody [EPR3924] - ER Marker (ab92516) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-Calreticulin antibody [EPR3924] - ER Marker (ab92516) has been confirmed by testing in knockout samples. Anti-Calreticulin antibody [EPR3924] - ER Marker (ab92516) has 6 independent reviews from customers. Anti-Calreticulin antibody [EPR3924] - ER Marker (ab92516) specifically detects Calreticulin (UniProt ID: P27797; Molecular weight: 46kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR3924 - ab271865 . Antibody clone EPR3924 is also available pre-conjugated to a variety of labels for your convenience - HRP, Alexa Fluor® 488, Alexa Fluor® 647, PE, Alexa Fluor® 405, Alexa Fluor® 555, Alexa Fluor® 594 ( ab195511 , ab196158 , ab196159 , ab209577 , ab210431 , ab275117 , ab275343 ). Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Mouse, Rat, Human, African green monkey

Application

WB, IHC-P, Flow Cyt (Intra), ICC/IF

Platform ID

BAB050386361

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Calreticulin antibody [EPR3924] - ER Marker
Cat. No.AB92516
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human, African green monkey
ApplicationWB, IHC-P, Flow Cyt (Intra), ICC/IF
ClonalityMonoclonal
Clone NumberEPR3924
Concentration0.429 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed : 7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed : 11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). See full target information CALR

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