Anti-Calreticulin antibody - ER Marker,Abcam,AB2907

Anti-Calreticulin antibody - ER Marker (ab2907) is a rabbit polyclonal antibody and is validated for use in ICC/IF, WB in human, mouse, rat samples. Anti-Calreticulin antibody - ER Marker (ab2907) has been cited over 256 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Calreticulin antibody - ER Marker (ab2907) has high sensitivity and specificity. Anti-Calreticulin antibody - ER Marker (ab2907) has 16 independent reviews from customers. Anti-Calreticulin antibody - ER Marker (ab2907) specifically detects Calreticulin (UniProt ID: P27797; Molecular weight: 46kDa) and is sold in 100 µL selling sizes. Calreticulin (CALR, HACBP) is a multifunctional protein involved in protein folding and calcium homeostasis within the endoplasmic reticulum. In oncology, it plays a crucial role in immunogenic cell death by acting as a signal for immune cells to target and destroy cancer cells. Calreticulin (CALR, HACBP) is also implicated in tumor progression and metastasis due to its role in cell adhesion and migration. As a result, it is being explored as a potential therapeutic target for cancer treatment.

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

ICC/IF, WB

Platform ID

BAB675398855

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Calreticulin antibody - ER Marker
Cat. No.AB2907
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationICC/IF, WB
ClonalityPolyclonal
ImmunogenRecombinant Full Length Protein corresponding to Human CALR.
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.05% Sodium azide
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed : 7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed : 11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). See full target information CALR

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