Anti-Caspase-2 antibody,Abcam,AB182657

Host

Rabbit

Reactivity

Human

Application

WB, IHC-P

Platform ID

BAB865341432

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Caspase-2 antibody
Cat. No.AB182657
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationWB, IHC-P
ClonalityPolyclonal
ImmunogenRecombinant Fragment Protein within Human CASP2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed : 11156409, PubMed : 15073321, PubMed : 8087842). Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed : 15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed : 15073321).. Isoform 1. Acts as a positive regulator of apoptosis.. Isoform 2. Acts as a negative regulator of apoptosis.. Isoform 3. May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death. See full target information CASP2

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