Anti-Caspase-9 antibody [EPR18107],Abcam,AB202068

What is this antibody validated in? Anti-Caspase-9 antibody [EPR18107] (ab202068) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse samples. What is the molecular weight of Caspase-9? Anti-Caspase-9 [EPR18107] (ab202068) specifically detects a band for Caspase-9 (UniProt: P55211) at a molecular weight of 46kDa. Trusted by the scientific community Anti-Caspase-9 [EPR18107] (ab202068) was first used in a scientific publication in 2015 and has been cited over 110 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-Caspase-9 antibody [EPR18107] (ab202068) has been confirmed by Western blot testing in CASP9 Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [EPR18107] also available for your convenience: ab202068, Carrier free - ab222231 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Mouse, Human

Application

IHC-P, IP, ICC/IF, WB

Platform ID

BAB928322451

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Caspase-9 antibody [EPR18107]
Cat. No.AB202068
HostRabbit
IsotypeIgG
ReactivityMouse, Human
ApplicationIHC-P, IP, ICC/IF, WB
ClonalityMonoclonal
Clone NumberEPR18107
Concentration1.389 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed : 36758105, PubMed : 36758106).. Isoform 2. Lacks activity is an dominant-negative inhibitor of caspase-9. See full target information CASP9

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