Anti-Caveolin-1 antibody [E249] - Caveolae Marker,Abcam,AB32577
What is this antibody validated in? Anti-Caveolin-1 antibody [E249] - Caveolae Marker (ab32577) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples. What is the molecular weight of Caveolin-1? Anti-Caveolin-1 [E249] - Caveolae Marker (ab32577) specifically detects a band for Caveolin-1 (UniProt: Q03135) at a molecular weight of 20kDa. Trusted by the scientific community Anti-Caveolin-1 [E249] - Caveolae Marker (ab32577) was first used in a scientific publication in 2006 and has been cited over 20 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 20µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-Caveolin-1 antibody [E249] - Caveolae Marker (ab32577) has been confirmed by Western blot testing in CAV1 Knockout HeLa cells. Other related products We have a range of other formats of antibody clone [E249] also available for your convenience: ab32577, Alexa Fluor ® 488 - ab185043 , Alexa Fluor ® 647 - ab193892 , HRP - ab193893 , Carrier free - ab230262 , APC - ab310857 , PE - ab310925 , Alexa Fluor ® 594 - ab311728 , Alexa Fluor ® 568 - ab313005 , Alexa Fluor ® 555 - ab313209 , Alexa Fluor ® 750 - ab321611 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
Flow Cyt, IHC-P, WB, ICC/IF
Platform ID
BAB366790736
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data May act as a scaffolding protein within caveolar membranes (PubMed : 11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed : 19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed : 17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed : 25893292). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). See full target information CAV1
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