Anti-Cdk6 antibody [EPR4515],Abcam,AB124821
What is this antibody validated in? Anti-Cdk6 antibody [EPR4515] (ab124821) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples. What is the molecular weight of Cdk6? Anti-Cdk6 [EPR4515] (ab124821) specifically detects a band for Cdk6 (UniProt: Q00534) at a molecular weight of 37kDa. Trusted by the scientific community Anti-Cdk6 [EPR4515] (ab124821) was first used in a scientific publication in 2012 and has been cited over 100 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-Cdk6 antibody [EPR4515] (ab124821) has been confirmed by Western blot testing in CDK6 Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [EPR4515] also available for your convenience: ab124821, Alexa Fluor® 488 - ab198944 , Alexa Fluor® 647 - ab198946 , Carrier free - ab222395 , PE - ab305713 , APC - ab305714 , HRP - ab305715 , Alkaline Phosphatase - ab308887 , Alexa Fluor® 594 - ab310613 , Alexa Fluor® 555 - ab312141 , Alexa Fluor® 568 - ab312627 , Alexa Fluor® 750 - ab320982 Species reactivity Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human
Application
IHC-P, WB, ICC/IF, Flow Cyt (Intra)
Platform ID
BAB133257828
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed : 23918663). See full target information CDK6
Category Paths
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