Anti-Chromogranin A antibody,Abcam,AB15160
Product Specifications Anti-Chromogranin A antibody (ab15160) is a rabbit polyclonal antibody and is validated for use in IHC-P in human samples. Anti-Chromogranin A antibody (ab15160) specifically detects Chromogranin A (UniProt ID: P10645; Molecular weight: 49kDa) and is sold in 100 µL, 500 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-Chromogranin A antibody (ab15160) has high sensitivity and specificity. Anti-Chromogranin A antibody (ab15160) has been cited over 238 times in peer reviewed journals and is trusted by the scientific community. Anti-Chromogranin A antibody (ab15160) has 29 independent reviews from customers. Target Information Chromogranin A (CgA) or parathyroid secretory protein 1 is encoded in the human by the gene CHGA. Chromogranin A (CgA) is found in the secretory vesicles of neuroendocrine cells and serves as a key biomarker in oncology. It is particularly useful in diagnosing and monitoring neuroendocrine tumors (NETs).
Host
Rabbit
Reactivity
Human
Application
IHC-P
Platform ID
BAB324699685
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Pancreastatin. Strongly inhibits glucose induced insulin release from the pancreas.. Catestatin. Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed : 15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed : 15723172, PubMed : 24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed : 21214543). Acts as a potent scavenger of free radicals in vitro (PubMed : 24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed : 18541522).. Serpinin. Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. See full target information CHGA
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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