Anti-Claudin 1 antibody [EPRR18871],Abcam,AB211737
What is this antibody validated in? Anti-Claudin 1 antibody [EPRR18871] (ab211737) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, samples. What is the molecular weight of Claudin 1? Anti-Claudin 1 [EPRR18871] (ab211737) specifically detects a band for Claudin 1 (UniProt: O95832) at a molecular weight of 22kDa. Trusted by the scientific community Anti-Claudin 1 [EPRR18871] (ab211737) was first used in a scientific publication in 2016 and has been cited over 30 times in peer-reviewed journals. Reviewed by scientists Anti-Claudin 1 [EPRR18871] (ab211737) has over 5 independent reviews from customers. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-Claudin 1 antibody [EPRR18871] (ab211737) has been confirmed by Western blot testing in CLDN1 Knockout A431 cells. Other related products We have a range of other formats of antibody clone [EPRR18871] also available for your convenience: ab211737, Carrier free - ab238949 , PE - ab303065 , APC - ab303066 , HRP - ab303067 , Alkaline Phosphatase - ab308713 , Alexa Fluor® 488 - ab309682 , Alexa Fluor® 647 - ab310044 , Alexa Fluor® 594 - ab310432 , Alexa Fluor® 555 - ab311958 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human
Application
IHC-P, ICC/IF, WB, IP, Flow Cyt (Intra)
Platform ID
BAB763467826
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed : 23407391).. (Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes (PubMed : 17325668, PubMed : 20375010, PubMed : 24038151). Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell (PubMed : 20375010). Acts as a receptor for dengue virus (PubMed : 24074594). See full target information CLDN1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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