Anti-Claudin 4 antibody,Abcam,AB53156

What is this antibody validated in? Anti-Claudin 4 antibody (ab53156) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples. What is the molecular weight of Claudin 4? Anti-Claudin 4 (ab53156) specifically detects a band for Claudin 4 (UniProt: O14493) at a molecular weight of 22kDa. Trusted by the scientific community Anti-Claudin 4 (ab53156) was first used in a scientific publication in 2007 and has been cited over 30 times in peer-reviewed journals.

Host

Rabbit

Reactivity

Human

Application

ICC/IF, IHC-P, WB

Platform ID

BAB888630248

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Claudin 4 antibody
Cat. No.AB53156
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationICC/IF, IHC-P, WB
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human CLDN4 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Can associate with other claudins to regulate tight junction structural and functional strand dynamics (PubMed : 35773259, PubMed : 36008380). May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity) (PubMed : 36008380). May integrate into CLDN3 strands to modulate localized tight junction barrier properties (PubMed : 35773259, PubMed : 36008380). May disrupt strand assembly of channel-forming CLDN2 and CLDN15 and inhibit cation conductance (PubMed : 35773259, PubMed : 36008380). Cannot form tight junction strands on its own (PubMed : 35773259, PubMed : 36008380). See full target information CLDN4

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