Anti-Claudin 5 antibody [EPR7583],Abcam,AB131259

Product Specifications Anti-Claudin 5 antibody [EPR7583] (ab131259) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC/IF, IHC-P, WB in human samples. Anti-Claudin 5 antibody [EPR7583] (ab131259) specifically detects Claudin 5 (UniProt ID: O00501; Molecular weight: 23kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-Claudin 5 antibody [EPR7583] (ab131259) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-Claudin 5 antibody [EPR7583] (ab131259) has been cited over 90 times in peer reviewed journals and is trusted by the scientific community. Anti-Claudin 5 antibody [EPR7583] (ab131259) has 7 independent reviews from customers. Related Products Conjugation-ready, carrier free format available for antibody clone EPR7583 - ab236066 . Antibody clone EPR7583 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, Alexa Fluor® 594, Alexa Fluor® 568, Alexa Fluor® 555, Alexa Fluor® 750 ( ab311000 , ab311126 , ab311758 , ab313038 , ab313239 , ab321040 ). Target Information Claudin-5 (CLDN5) is an integral membrane protein that forms tight junctions in endothelial cells, crucial for the blood-brain barrier's (BBB) function. It ensures the selective permeability of the BBB, preventing harmful substances from entering the brain. Abnormal expression of Claudin-5 is associated with several neurological conditions, such as epilepsy, Alzheimer's disease, and schizophrenia, highlighting its importance in maintaining BBB integrity and brain health. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Species reactivity Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.