Anti-Collagen III antibody,Abcam,AB7778

Anti-Collagen III antibody (ab7778) is a rabbit polyclonal antibody and is validated for use in ELISA, ICC, ICC/IF, IHC-P, IP, WB in mouse samples. Anti-Collagen III antibody (ab7778) has been cited over 649 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Collagen III antibody (ab7778) has high sensitivity and specificity. Anti-Collagen III antibody (Colagen type 3) (ab7778) has 21 independent reviews from customers. Anti-Collagen III antibody (ab7778) specifically detects Collagen III (UniProt ID: P02461; Molecular weight: 95kDa) and is sold in 100 µg selling sizes. For more protocol tips, please see : Collagen Target Tips At least 11 genetically distinct gene products are collectively referred to as 'collagen types' or other proteins and proteoglycans of the extracellular matrix. In humans, collagens are composed of about 20 unique protein chains which under go various types of post-translational modifications and are ultimately assembled into a triple helix. This results in great diversity between collagen types. Collagens are highly conserved throughout evolution and are characterized by an uninterrupted "Glycine-X-Y" triplet repeat that is a necessary part of the triple helical structure. For these reasons it is often extremely difficult to generate antibodies with specificities to collagens. The development of type specific antibodies is dependent on NON-DENATURED three-dimensional epitopes. This preparation results in a native conformation of the protein.

Host

Rabbit

Reactivity

Human, Rat, Cow

Application

IP, ELISA, ICC/IF, WB, IHC-P

Platform ID

BAB266416410

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Collagen III antibody
Cat. No.AB7778
HostRabbit
IsotypeIgG
ReactivityHuman, Rat, Cow
ApplicationIP, ELISA, ICC/IF, WB, IHC-P
ClonalityPolyclonal
Concentration1.16 mg/mL Batch dependent concentration
ImmunogenNative Full Length Protein corresponding to Human COL3A1.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.01% Sodium azide Constituents: 0.88% Sodium chloride, 0.424% Potassium phosphate solution
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. See full target information COL3A1

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