Anti-Collagen IV alpha 1 antibody,Abcam,AB189408

Host

Rabbit

Reactivity

Human

Application

IHC-P

Platform ID

BAB828947645

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Collagen IV alpha 1 antibody
Cat. No.AB189408
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIHC-P
ClonalityPolyclonal
ImmunogenNative Full Length Protein corresponding to Human COL4A1.
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.09% Sodium azide
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. See full target information COL4A1

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