Anti-Collagen IV antibody [1043],Abcam,AB86042

In IHC, recognizes the extracellular – basement membranes. We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result, we are pleased to offer this antibody in a purified format as of 27 th October 2017. The following lots are still unpurified and still in stock as of 27 th October 2017- GR275641-7, GR275641-13, and GR275641-14. Lot numbers other than GR275641-7, GR275641-13, and GR275641-14 will be purified. Please note that the dilutions may need to be adjusted accordingly. Purified antibodies have the advantage of being enriched for the fraction of immunoglobulin that specifically reacts with the target antigen and for having a reduction of serum proteins.

Host

Mouse

Reactivity

Human

Application

IHC-P, IHC-Fr

Platform ID

BAB766466386

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Collagen IV antibody [1043]
Cat. No.AB86042
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationIHC-P, IHC-Fr
ClonalityMonoclonal
Clone Number1043
Concentration1 mg/mL Batch dependent concentration
ImmunogenNative Full Length Protein corresponding to Human COL4A1.
PurityAffinity purification
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.09% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. See full target information COL4A1

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