Anti-Collagen IV antibody,Abcam,AB6586

Anti-Collagen IV antibody (ab6586) is a rabbit polyclonal antibody and is validated for use in ELISA, ICC/IF, IF, IHC-FoFr, IHC-Fr, IHC-FrFl, Anti-Collagen IV antibody (ab6586) was first used in a scientific publication in 2004 and has been cited over 920 times in peer reviewed journals. It's performance in IHC and Western Blot in human, mouse and rat samples is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Collagen IV antibody (ab6586) has high sensitivity and specificity. Anti-Collagen IV antibody (ab6586) has 120 independent reviews from customers. Anti-Collagen IV antibody (ab6586) specifically detects Collagen IV (UniProt ID: P02462; Molecular weight: ~160kDa) and is sold in 100 µg selling sizes. Collagen IV is a key component of the extracellular matrix in tumors, contributing to tissue stiffness and promoting cancer cell invasion. It plays a significant role in tumor progression and metastasis, influencing the behaviour of cancer cells.

Host

Rabbit

Reactivity

Human, Hamster, Syrian hamster, Cow, Mouse, Dog, Zebrafish, Rat, Chinese hamster, African green monkey, Pig

Application

IHC-FrFl, IHC-P, IF, ICC/IF, IHC-Fr, WB, IP, IHC-FoFr, ELISA

Platform ID

BAB016491374

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Collagen IV antibody
Cat. No.AB6586
HostRabbit
IsotypeIgG
ReactivityHuman, Hamster, Syrian hamster, Cow, Mouse, Dog, Zebrafish, Rat, Chinese hamster, African green monkey, Pig
ApplicationIHC-FrFl, IHC-P, IF, ICC/IF, IHC-Fr, WB, IP, IHC-FoFr, ELISA
ClonalityPolyclonal
Concentration1.18 mg/mL Batch dependent concentration
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.01% Sodium azide Constituents: 0.88% Sodium chloride, 0.424% Potassium phosphate solution
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. See full target information COL4A1

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