Anti-Connexin 43 / GJA1 antibody - C-terminal - Intercellular Junction Marker,Abcam,AB219493

What is this antibody validated in? Anti-Connexin 43 / GJA1 antibody - C-terminal (ab219493) is a goat polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in African green monkey, Human samples. What is the molecular weight of Connexin 43 / GJA1? Anti-Connexin 43 / GJA1 - C-terminal (ab219493) specifically detects a band for Connexin 43 / GJA1 (UniProt: P08050) at a molecular weight of 43kDa.

Host

Goat

Reactivity

Human, African green monkey

Application

WB, IHC-P, ICC/IF

Platform ID

BAB329697285

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Connexin 43 / GJA1 antibody - C-terminal - Intercellular Junction Marker
Cat. No.AB219493
HostGoat
IsotypeIgG
ReactivityHuman, African green monkey
ApplicationWB, IHC-P, ICC/IF
ClonalityPolyclonal
Concentration4 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Rat Gja1 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity : acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). See full target information GJA1

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