Anti-Connexin 43 / GJA1 antibody - Intercellular Junction Marker,Abcam,AB235282

Target data Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity : acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization (PubMed : 15181016). Plays an essential role in gap junction communication in the ventricles (PubMed : 26403541).. Connexin 43 is possibly the ATP-induced pore of mouse macrophages. See full target information Gja1